Skelet make up
A b c d Rajkumar, S Vincent; Dimopoulos, Meletios A; Palumbo, Antonio; Blade, Joan; Merlini, Giampaolo; Mateos, María-Victoria; Kumar, Shaji; Hillengass, Jens; Kastritis, Efstathios (November 2014).
48 The prognoses for patients with multiple myeloma, as those with other diseases, are not the same for everyone.
Citation needed Prognostic markers such as these are always generated by retrospective analyses, and it is likely that new treatment developments will improve the outlook for those with traditionally "poor-risk" disease.Myeloma cells produce monoclonal proteins of varying types, most commonly immunoglobulins (antibodies) and free light chains, resulting in abnormally high levels of these proteins in the blood.97 (Suppl 1 214.Rankl activates osteoclasts, which resorb bone."Plasma Cell Neoplasms gebruikershandleiding maken (Including Multiple Myeloma) Treatment".
A b Greipp PR, San Miguel J, Durie BG,.
Myeloma activity sometimes appears as "lytic lesions" (with local disappearance of normal bone due to resorption and on the skull X-ray as "punched-out lesions" (pepper pot skull).Although the total immunoglobulin level is typically elevated in multiple myeloma, the majority of the antibodies are ineffective monoclonal antibodies from the clonal plasma cell.International Myeloma Working Group.In addition to addressing symptoms of cancer, palliative care helps manage unwanted side-effects, such as pain and nausea related to treatments.Allogeneic stem cell transplantation, the transplantation of a healthy persons stem cells into the affected patient, has the potential for a cure, but is used in a very small percentage of patients (and in the relapsed setting, not as part of initial treatment)."The use of intravenous immune globulin in multiple myeloma".Retrieved 29 September 2017.Textbook of Veterinary Internal Medicine: Diseases of the Dog and Cat.Diagnosis usually involves bone marrow studies, X-rays, and plasma protein studies.EBV-positive disease is more common in the plasmacytoma rather than multiple myeloma form of plasma cell maligancy.
"The diagnosis and characteristics of renal heavy-chain and heavy/light-chain amyloidosis and their comparison with renal light-chain amyloidosis".
Involvement of the vertebrae may lead to spinal cord compression or kyphosis.